TSC2 and tuberous sclerosis: However, we cannot insist that everolimus would have therapeutic effect specifically on ASD or epilepsy in patients with TSC induced by TSC2 c.700–701 del mutation because grandmother and father carrying TSC2 c.700–701 del mutation has normal intelligence without epilepsy or neuropsychiatric symptoms and we could not suggest an evidence of genotype (TSC2 c.700–701 del mutation)-phenotype correlation in TSC patient.