In the common differentially expressed mRNAs analysis, ECRSwNP and non-ECRSwNP share many common dysregulated genes in inflammatory and immune response and extracellular matrix microenvironment, including staphylococcus aureus infection, HIF-1 signaling pathway, and cell adhesion molecules, but they also have their own distinctive characteristics. The gene discussed is HIF1A; the disease is staphylococcus aureus infection.