As expected15, 16, 17, gene set enrichment analysis (GSEA) demonstrates that those CpGs that are hypermethylated in the fimbrial versus proximal end of the fallopian tube in BRCA1/2 mutation carriers are associated with cancer development (Supplementary Data 3) and are notably enriched for cancer or stem cell genes and genes targeted by EED (a component of the polycomb repressor complex 2, PRC2) or marked by H3K27me3. The gene discussed is BRCA1; the disease is cancer.