Utilizing the ChIP-seq data sets from our previous study (Fig. 1a)13, we analyzed the H3K4me3, H3K27me3 and H3K79me2 status throughout the genomes of the HCT116 CRC cell line and isogenic DNMT1/DNMT3B double-knockout cells (DKO2), in which global DNA methylation is almost completely eliminated18 (Fig. 1b, Supplementary Figure S1). The gene discussed is DNMT3B; the disease is colorectal carcinoma.