MEG3 and colorectal adenocarcinoma: For instance, maternally expressed gene 3 (MEG3) is reportedly downregulated in association with promoter hypermethylation in meningioma and ovarian and gastric cancers20, 21, 22, and a recent deep bisulfite sequencing analysis identified hypermethylation of the lncRNA gene colorectal adenocarcinoma hypermethylated (CAHM) in CRC23.