For instance, maternally expressed gene 3 (MEG3) is reportedly downregulated in association with promoter hypermethylation in meningioma and ovarian and gastric cancers20, 21, 22, and a recent deep bisulfite sequencing analysis identified hypermethylation of the lncRNA gene colorectal adenocarcinoma hypermethylated (CAHM) in CRC23. This evidence concerns the gene MEG3 and meningioma.