CA9 and Ito hypomelanosis: Using live imaging and assessment of expression of hypoxia-inducible genes we were able to detect and quantify hypoxia-related changes through the expression of carbonic anhydrase (CAIX) and the genes Pgk1, Glut1, Vegfa, Hprt, Nos2, Car9 (CAIX) and Hif1α within the lungs of mice suffering from IPA.