Another important point to notice is that Survivin plays an important role in response to Radiotherapy too; a high level of Survivin has been shown to increase both the resistance to Radiotherapy and the incidence of local recurrence in rectal cancer patients [18] and is associated with worsened survival in patients treated with definitive Radiotherapy for cervical cancer [7, 19]. This evidence concerns the gene BIRC5 and rectal cancer.