We have defined a tumor cell and macrophage-driven signaling network operating within the environment of ovarian cancer-associated carcinomatosis involving interleukins, chemokines, members of the TGFβ, WNT, S100, semaphorin and ephrin families, the phospholipid breakdown products LPA, and AA as well as AA metabolites. The gene discussed is TGFB1; the disease is neoplasm.