We also found tumor cell selective expression of the NDP, FZD4, and TSPAN12 genes (Fig. 4c, f, g), encoding norrin, its receptor frizzled 4, and a norrin signal-amplifying component of the receptor complex, respectively [55], which were linked to colon cancer angiogenesis in a recent study [61]. Here, TSPAN12 is linked to malignant colon neoplasm.