Genes identified by this approach in tumor cells (n = 35; Table 1) and TAMs (n = 14; Additional file 4: Table S4) may indeed be of high relevance, as they code for components of chemokine, TGFβ/BMP, FGF, ephrin, semaphoring, and WNT pathways. This evidence concerns the gene TGFB1 and neoplasm.