Furthermore, multiple receptors interacting with different S100 proteins or S100A8/A9 heterodimers are expressed by both tumor cells and TAMs (SCARA/B, CD36), preferentially by TAMs (AGER, MSR1, TLR4) or by tumor cells (ERBB2), pointing to extensive functional interactions between both cell types. The gene discussed is TLR4; the disease is neoplasm.