IGF1 and neoplasm: These include: (1) stimulation of the MET receptor on tumor cells by TAM-produced HGF; (2) the interaction of amphiregulin (AREG) produced by both cell types with ERB2, 3, and 4 receptors on tumor cells; (3) the activation of NOTCH receptors on both cell types by JAG1/2 ligands, mainly produced by tumor cells; (4) PDGF signaling by all different family members via PDGFR-A on both cell types; (5) IGF1/2 signaling particularly through IGFR2; and (6) the interaction of angiopoietin-like 4 (ANGPTL4) with integrin β1 (ITGB1).