IGFBP2 and idiopathic pulmonary fibrosis: IGFBP-2 seems to be significantly lowered by specific IPF therapy irrespective of the molecule used as anti-fibrotic treatment (median range of 189 (110–231) ng/ml in the group treated by nintedanib (n = 9) vs 155 (126–192) ng/ml in those receiving pirfenidone (n = 17), p > 0.05).