TARDBP and amyotrophic lateral sclerosis: Some of the most widespread diseases exhibit hallmark protein aggregates such as Alzheimer's disease (AD) with β-amyloid plaques (Glenner and Wong, 1984) and neurofibrillary tau tangles (Kosik et al., 1986), Parkinson's disease with Lewy bodies containing α-synuclein (Spillantini et al., 1998), and amyotrophic lateral sclerosis (ALS) with the aggregation of TDP43 (Neumann et al., 2006).