TNF and rheumatoid arthritis: We have previously reported that minor allele carriage at rs12212067, a noncoding SNP in FOXO3, is associated with a milder course of several TNF‐driven diseases, including RA, and we have described a FOXO3‐dependent pathway that is regulated by this genetic variant and which modulates inflammatory responses in monocytes via TGFβ1 induction 10.