Given these data and the TGFβ1‐driven inflammatory pathway that FOXO3 has been shown to regulate 10, we postulated that the effect of FOXO3A on radiographic outcome might be mediated by a reduction of inflammation and not by a direct effect on the bone, as has been suggested for other genetic markers of RA severity 5. The gene discussed is TGFB1; the disease is rheumatoid arthritis.