In RA specifically, we showed that minor allele carriage at rs12212067, which reduced the production of TNF, interleukin‐6 (IL‐6), IL‐1β, and IL‐8 and increased the production of IL‐10, was associated with a milder disease course (i.e., less joint damage over time) in large and well‐phenotyped cohorts of patients with early disease. This evidence concerns the gene TNF and rheumatoid arthritis.