ALDH2 has a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation.16 Recent studies have shown that accelerated detoxification of toxic aldehydes through the activation of ALDH2 by Alda-1 attenuated NAFLD as well as alcohol-induced hepatic steatosis.9, 17 In the present study, we found significant influences of the ALDH2*2 allele on the risk for NAFLD, without any increases in the patient body weight among nondrinkers as well as all subjects. The gene discussed is ALDH2; the disease is metabolic dysfunction-associated steatotic liver disease.