Transcripts for several genes in this pathway became more abundant following TDV vaccination, including DDX58 (RIG-I), EIF2AK2 (PKR), STAT1, IRF7, OASL and OAS2, MX1, IFI44, ISG15, and XAF1. The magnitude of the type I IFN response was much greater following infection with wt DENV, which might reflect greater replication and increased immunogenicity of the wt virus compared with vaccine viruses. Here, ISG15 is linked to infection.