RIGI and infection: Transcripts for several genes in this pathway became more abundant following TDV vaccination, including DDX58 (RIG-I), EIF2AK2 (PKR), STAT1, IRF7, OASL and OAS2, MX1, IFI44, ISG15, and XAF1. The magnitude of the type I IFN response was much greater following infection with wt DENV, which might reflect greater replication and increased immunogenicity of the wt virus compared with vaccine viruses.