TGFB2 and myopia: Nonetheless, it is plausible that TGF-β2 protein secreted from the basal side of the RPE could act on the adjacent choroid to trigger another step in the signal transduction cascade and/or diffuse to the sclera to regulate its remodeling after activation.[48, 55] Either way, the RPE and TGF-β2 would seem plausible targets for controlling myopia.