The primary tumor harbored a heterozygous c.121A>G/p.T41A CTNNB1 mutation (Fig 3A), whereas the Wilms10 tumor cell culture carried a homozygous deletion of three nucleotides c.133-135 del TCT, leading to loss of amino acid S45 (p.S45Δ) (Fig 3B). The gene discussed is CTNNB1; the disease is neoplasm.