The average plasma c-Met levels in the tissue c-Met-negative group were 602.72 ± 135.59 ng/ml (95% CI: 403.42 - 873.86) before EGFR-TKI treatment, 531.47 ± 128.85 ng/ml (95% CI: 333.44 - 755.92) at the time of the best tumor response, and 601.55 ± 120.94 ng/ml (95% CI: 386.24 - 881.84) with PD. This evidence concerns the gene EGFR and neoplasm.