For instance, besides understanding how additional regulators such as RASSF1A, RASSF6 or HSP90 play their specific roles, we have yet to uncover how MOB1, as a central hub of the Hippo pathway, may differentially interact with NDR1/2 and LATS1/2 and thereby potentially play diverse tumour suppressive roles. This evidence concerns the gene LATS1 and neoplasm.