MAP3K11 and cancer: In certain cancer models, MLK3 is required for EGF-induced B-Raf activation by providing scaffolding for Raf-1/B-Raf complex; thus this scaffolding function of MLK3 allows Ras-dependent, activated Raf-1 to phosphorylate and activate B-Raf, resulting in increased ERK activity [26,45].