This may be related to unchanged hepatic Angptl8 mRNA expression, because Quagliarini et al. [59] recently demonstrated that the plasma triglyceride level was not altered in mice expressing Angptl3 alone, but coexpression of Angptl8 leads to hypertriglyceridemia despite a reduction in the circulating Angptl3 level. Here, ANGPTL3 is linked to hypertriglyceridemia.