For example, multiple myeloma-derived exosomes internalized by the Raw264.7 cell lines and human primary osteoclast, increased expression of osteoclast marker, including Cathepsin K, Metalloproteinases 9, and Tartrate-resistant Acid Phosphatase (TRAP), thus promoting the maturation of osteoclasts [60]. This evidence concerns the gene ACP5 and AL amyloidosis.