To determine if restoring SERCA2 levels would be therapeutic in pulmonary hypertension, gene transfer of human SERCA2a using an adeno-associated virus serotype 1 (AAV1.SERCA2a) via aerosolized inhalation was performed in the rat monocrotaline model and the porcine pulmonary vein banding model of pulmonary hypertension [63,64,65]. This evidence concerns the gene ATP2A2 and pulmonary arterial hypertension.