Table 5 shows that the GA and GA + AA genotypes of IGF1R rs2229765 demonstrated significant association with L858R mutation in female lung adenocarcinoma patients (OR = 0.35, 95% CI = 0.14–0.88 and OR = 0.34, 95% CI = 0.14–0.84, respectively). These results indicate that the polymorphisms of IGF1R rs2229765 gene are associated with L858R mutation in female adenocarcinoma patients. Here, IGF1R is linked to adenocarcinoma.