GPER-dependent aldosterone effects have been shown in vascular smooth muscle [29] and endothelial cells—where aldosterone’s endothelium-dependent vasodilator effects have been shown to be GPER-dependent [24], in breast cancer cells [30], in cardiomyocytes [31], in cardiac vagal neurons [32], in renal connecting tubules [33]. This evidence concerns the gene GPER1 and breast carcinoma.