Jin et al. [45] have showed that PKC/JNK/SP1 pathway implicates in the regulation of CYP2E1 enzymes in ethanol-mediated oxidative stress, whereas Zeng et al. [50] has recently revealed that PI3K/Akt activation might be involved in acute ethanol-induced liver diseases in mice, but not with MAPK signaling. The gene discussed is MAPK8; the disease is liver disorder.