The oncogenic miR-21, miR-337, miR-543, miR-214 and miR-130 are known to induce tumour-associated neovascularisation by directly targeting PTEN and activating PI3K/AKT, as well the ERK1/2 signaling pathways, which increases HIF1α and vascular endothelial growth factor (VEGF) expression [65,66,67,68,69]. This evidence concerns the gene AKT1 and neoplasm.