Upregulation of miR-126 in MM cells decreased the ACL activity, inducing citrate accumulation in the cytoplasm and stabilisation of HIF-1, which is a critical transcription factor in various cellular and physiologic processes, as it can facilitate the adaption of tumour cells to hypoxia by the activation of the transcription of downstream target genes and by regulation of multiple aspects of tumorigenesis. Here, HIF1A is linked to Miyoshi myopathy.