Another well-known target is KEAP1 (Kelch-Like ECH-Associated Protein 1), a stress sensing adaptor for the Cullin3-dependent E3 ubiquitin ligase complex, that negatively regulates the NFE2L2 (Nuclear Factor, Erythroid 2-Like 2) transcription factor [71,72], whose upregulation causes paclitaxel resistance in cancer cell lines [73,74,75]. This evidence concerns the gene KEAP1 and cancer.