CYP1B1 and neoplasm: Methoxylated stilbenes also exhibit biological activities not seen in demethoxylated stilbene (e.g. resveratrol), for example, pterostilbene inhibits human recombinant cytochrome P450 CYP1A1 and CYP1B1, key enzymes involved in the detoxification of toxins or drugs [42], and also induces apoptosis in tumor cells via the caspase cascade in mitochondria [43].