In mouse models, yeast expressing HCV NS3-Core fusion protein induced antigen-specific cytotoxic T cell responses that resulted in eradication of circulating cells expressing the antigen [33, 34], and yeast expressing mutant BCR-ABL oncogene protein, used as a subcutaneous vaccine, eliminated leukemia cells expressing this mutant protein [35]. The gene discussed is KRAS; the disease is leukemia.