MYC and Cognitive impairment: Interestingly, all of them were already shown to be overexpressed in AD brain [38–40]. MYC, which presented the greatest fold change expression in our casuistic is reported to be overexpressed in degenerating neurons, and its expression in transgenic mice induces neuronal-specific cell cycle re-entry, neurodegeneration, and, importantly, significant cognitive deficits [39].