MC4R and diabetes mellitus: However, Qi et al. [21] have shown that the MC4R C allele is significantly associated with high intakes of total energy (P = 0.028), total fat (P = 0.008) and protein (P = 0.003) after adjustment for age, BMI, and diabetes status; although the associations between MC4R rs17782313 and BMI were significant (P = 0.002) independent of dietary intakes.