MAPK14 and liver dysplastic nodule: In this study, we examined the effects of BPS treatment on streptozotocin-induced diabetic rats fed with high-fat diet (HFD), a type 2 DM animal model, and investigated the mechanisms underlying the protective action of BPS in DN induced by inflammation and activation of p38 signaling pathway; in addition, we explored whether the protective effects were mediated by inhibition of the p38 MAPK signaling pathway.