There can be two sources of such T cells: (1) natural host T cells identified in the tumour, the autologous tumour infiltrating lymphocytes (TILs), and (2) T cells from patients' blood that have been genetically engineered ex vivo with specific antitumour T cell receptors (TCRs) or chimeric antigen receptors (CARs) [105]. Here, CARS1 is linked to neoplasm.