Based on these facts, the aim of this work was to explore the production of autoantibodies to VEGFR-3 in BDL-induced cholestatic liver injury and investigate whether absorbances associated with the serum levels of autoantibodies to VEGFR-3 are correlated with traditional markers of liver damage, cholestasis, and fibrosis. The gene discussed is FLT4; the disease is cholestasis.