IGHE and Alzheimer disease: They also showed in another paper and proved the impact of the IL-4 -590 C/T transition on the levels of Plasmodium falciparum specific IgE, IgG, and IgG subclasses and total IgE in two sympatric ethnic groups living in Mali [18] but there were few studies focusing on association between IL-4 SNPs and the occurrence and development of AD.