PTPN1 and Insulin resistance: Our study first confirmed that a low dosage of PZI (a half dosage of PZI alone) combined with Se significantly improved the animals’ general characteristics (food and water volume and decrease in BW), decreased the FBG levels, alleviated glucose and insulin resistance, and mitigated skeletal muscle and mitochondrial injury, accompanied by an increase in the PI3K levels and downregulation of PTP1B.