ERVW-1 and myeloid sarcoma: In all instances, superantigenic effects cause antigen-independent polyclonal activation of T lymphocytes, which was incriminated in MS (Rudge, 1991) and was more recently experimentally evidenced with MSRV-Env induction of autoimmunity against the central nervous system myelin proteins in animal models (Perron et al., 2013).