In other work, Giacomet and colleagues showed an increased number of activated CD4 + and CD8 + T cells (CD25 +, HLA − DR +, CD69 +) in an infant with congenital HIV infection, who, after 3 years of age, despite repeatedly testing negative for HIV antibodies, HIV DNA, p24, and HIV RNA was not cured (Giacomet et al., 2014). This evidence concerns the gene CD4 and HIV infectious disease.