The presence of premature termination codons can lead to degradation of mRNA transcripts by nonsense-mediated RNA decay (NMD).41 We thus investigated whether the aberrantly spliced ABCB7 transcript containing a premature termination codon that we identified in SF3B1-mutant MDS is affected by NMD. This evidence concerns the gene ABCB7 and myelodysplastic syndrome.