Importantly, cryptic splicing events affecting TMEM14C, ENOSF1, DYNLL1 and HINT2 have been associated with SF3B1 mutation in other cancers such as chronic lymphocytic leukemia, uveal melanoma and breast cancer.21, 22, 23 Emerging evidence thus suggests that there are several common downstream target genes in SF3B1-mutant malignancies, which may have implications for the design of new therapies for this group of cancers. Here, HINT2 is linked to B-cell chronic lymphocytic leukemia.