Aberrant splicing of ABCB7 has been reported recently in an isogenic SF3B1-mutant pre-B ALL cell line in another study.39 We suggest that downregulation of the iron exporter ABCB7 resulting from aberrant splicing of the mRNA transcript leading to NMD underlies the increased mitochondrial iron accumulation found in MDS patients with RS. Here, ABCB7 is linked to acute lymphoblastic leukemia.