HINT2 and myelodysplastic syndrome: Aberrant splicing of SEPT6 and HINT2 introduces an addition of 17 and 11 base pairs, respectively, leading to a frameshift in SEPT6 and to the rise of a premature termination codon in the first 3 base pairs of exon 5 in HINT2. The RT-PCR results confirmed the cryptic splicing events identified by RNA-Seq in these five genes in MDS patient samples with SF3B1 mutation (Figures 2a and b).