Taken together, our data show that MDS-associated SF3B1 mutations result in widespread use of cryptic 3′ splice sites a short distance upstream of canonical sites and could be consistent either with use of a common BP in association with upstream cryptic and canonical splice site pairs28 or, more likely, with shifted use of both BP and consequently 3′ splice site in the SF3B1-mutant,39, 40 as shown in recent reports in other cancers. The gene discussed is SF3B1; the disease is cancer.