SF3B1 and myelodysplastic syndrome: A number of studies to date have used RNA sequencing (RNA-Seq) on unfractionated bone marrow mononuclear cells from a small number of SF3B1-mutant MDS patients.10, 18, 19 MDS is a disorder of the HSC and we thus studied the transcriptome of CD34+ cells from MDS patients with SF3B1 mutations using RNA-Seq.