After filtering, network analysis8 was performed on BCR sequencing data verifying clonality in all B-ALL primary diagnostic samples (largest cluster sizes of 5.7–83.64% of the total BCR repertoire) and the day 567 sample from patient 1703 (largest cluster 3.83%) (Supplementary Table S1). The gene discussed is BCR; the disease is precursor B-cell acute lymphoblastic leukemia.