Astrocytes possibly play a constitutive role in the very early AD stages by taking up oligomeric sAβ, while microglia mainly function in the late stages as fAβ accumulates to form fibrillar deposits (Condello et al., 2015; Mulder et al., 2014; Weldon et al., 1998). The gene discussed is FANCB; the disease is Alzheimer disease.