SIRT1 and Alzheimer disease: SIRT1 is the most conserved member of sirtuins, a family of NAD+-dependent protein deacetylases, and contributes to deacetylation of multiple mammalian transcription factors such as p53, FOXOs, and NF-κB in nucleus, making it a key metabolic regulator involved in a vast number of cellular processes associated with age-related diseases including AD (Guarente, 2011; Herskovits and Guarente, 2014).