Functionally, in a TEM assay, this resulted in a 1.5-fold increase of monocytes, which crossed the endothelial layer (transmigrated cells/mm2: controls 36 ± 24; RA, DMARD 41 ± 19 p = ns versus controls; RA, TNF inhibition 57 ± 17, p = <0.05 versus all other groups) (Fig. 2b, c). The gene discussed is TNF; the disease is rheumatoid arthritis.