Likewise, the median OD level of aß2GPI IgG in aPL+ carriers (0.1, 95 % CI 0.1, 48.0) was significantly reduced in contrast to the one in APS patients (65.0, 95 % CI 46.8, 93.2, p = 0.0066). This evidence concerns the gene FASLG and autoimmune polyendocrinopathy.