[72]). Others, such as ETS-1, ERG and FLI-1, have a restricted profile of expression and are important in the regulation of tissue-specific processes that include haematopoiesis, angiogenesis and vascular inflammation. Several ETS factors including ETS-1, ETS-2, PU-1 (SPI1), FLI-1, ERG and TEL (ETV6) can act as proto-oncogenes and have been implicated in the pathogenesis of different types of cancer (reviewed in Ref. [88]). This evidence concerns the gene SPI1 and cancer.