SHOX and Léri-Weill dyschondrosteosis: Benito-Sanz et al. (2012) identified a 47-kb deletion downstream of SHOX as the disease-causing allele in Léri-Weill dyschondrosteosis (LWD) and idiopathic short stature (ISS) patients. Chen et al. (2009) also reported that microdeletions located 250 kb downstream of this gene can lead to short stature.