Indeed, increased neuro-inflammation has been reported in the brain of patients with depression; for example, postmortem studies have found an increased proportion of primed microglia and higher mRNA levels of several chemokines involved in the recruitment of monocytes (Torres-Platas et al., 2014); and a recent neuroimaging study has found increased microglia activation (translocator protein density) using positron emission tomography (Setiawan, et al., 2015). This evidence concerns the gene TSPO and depressive symptom measurement.