All these conditions are autoimmune and include characteristics contributing to hypercoagulability which include: chronic inflammation (release of cytokines, expression of tissue factors, endothelial dysfunction, inhibition of protein C), increased levels of PAI-1 and antiphospholipid antibodies, as well as a number of other factors such as elevated levels of fibrinogen and TF [6, 7, 30–33]. The gene discussed is SERPINE1; the disease is endothelial dysfunction.