FLNA and prostate neoplasm: These results clearly demonstrate that Cao2+ stimulates CaR-mediated signaling rather than Ca2+ entry or Ca2+ channels to promote the cleavage of filamin A. Recently, we and others reported that expression of the CaR is significantly up-regulated in DU145, PC-3 and C4-2B cells as compared with LNCaP cells, and prostate tumor tissue as compared with normal prostate tissue [26, 27].