Focusing on variation with diagnoses within each cortical region, there were significantly lower levels of PPIA, SNCA and NOL9 mRNA as well as a strong trend towards significantly lower levels of GAPDH in BA 8 and a trend to lower levels of SKP1 in BA 9 from subjects with schizophrenia compared to control (Fig. 2). The gene discussed is SKP1; the disease is schizophrenia.