Consistently, NLRP3 silencing resulted in a 5-fold reduction in the number of tumor-associated myeloid-derived suppressor cells found in host mice, and NLRP3−/− MDSCs were less efficient to reach the tumor site, demonstrating the critical role of NLRP3 in preventing cancer occurrence by modulating host immunity [99]. This evidence concerns the gene NLRP3 and neoplasm.