In fact, BCL2(Tg)/lpr-transgenic mice exhibit substantially enhanced lymphadenopathy compared with lpr or BCL2(Tg) only mice, which is mainly explained by the enhanced accumulation of both immature double negative (CD4−/CD8−) and double positive (CD4+/CD8+) T-cells [28]. This evidence concerns the gene CD8A and Lymphadenopathy.