In the present study, we focused on the function of Hbp1. Previous studies have indicated that Hbp1 regulates proliferation and senescence, and inhibits Wnt signaling.31, 32 Recent evidence suggests that the Hbp1 gene is frequently mutated in breast cancer33 and leukemia.34 We provided the first evidence that the genetic ablation of Hbp1 activated mitochondrial biogenesis without altered glycolysis in contrast to PTEN and TP53. Here, TP53 is linked to leukemia.